Regulation of root development in Arabidopsis
Our major research focus is to identify molecular mechanisms that underlie the quantitative regulation of organ growth. Using the Arabidopsis root as a model, we combine high throughput imaging at the cellular and organ level, genome-wide association studies (GWAS) and systems biology approaches to identify genes and gene networks underlying the tuning of root growth.
Meijón M, Satbhai SB, Tsuchimatsu T, Busch W (2013) Genome-wide association study using cellular traits identifies a new regulator of root development in Arabidopsis. Nature Genetics doi:10.1038/ng.2824
Busch W, Moore BT, Martsberger B, Mace DL, Twigg RW, Jung J, Pruteanu-Malinici I, Kennedy SJ, Fricke GK, Clark RL, Ohler U, Benfey PN (2012) A microfluidic device and computational platform for high-throughput live imaging of gene expression. Nat. Methods online: 30 Sep 2012.
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Tsukagoshi H, et al. (2010). Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root. Cell 143:606-616.
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